By Peter L. Steponkus
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Innate Immunity has lengthy been considered as the non-specific arm of immune reaction, appearing instantly and in a widespread approach, to protect the host from infections. within the put up genomic period, our wisdom of the innate immune approach is enriched by way of findings at the specificity of innate immune reactions in addition to to novel features that don't strictly correlate with immunological protection and surveillance, immune modulation or irritation.
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Additional resources for Advances in Low-Temperature Biology, Volume 3
1992). The results of this pilot feasibility study to evaluate a technique of complete blood substitution under conditions of ultraprofound hypothermia clearly demonstrated that the procedure yields an encouraging number of survivors after 2 to 3 hours of hypothermic cardiac arrest. On the basis of life or death outcome alone. Figure 6 shows that consistent revival of animals was achieved if the ultraprofound hypothermic interval was limited to less than 160 minutes. At longer periods of cardiac arrest the procedure was associated with some non-survivors, irrespective of the nadir temperature.
E. BAILES period of asanguineous perfusion used was reported to be as high as 8 hours with a hematocrit of 2%. , 1972; Agostini, 1973; 1974). Later in the 1980s, brief accounts—not substantiated by full reports—claimed success in achieving blood substitution in hamsters (Gan, 1985) and dogs (Segall, 1987), but no details of the technique or the neurological or functional outcome could be found in the literature. As shown in Table 3, all of the previously described studies have used an extracellular based solution and some attempted to use a colloid- or a plasma-based solution; but Kondo et al.
A brief summary of the most significant experimental reports relating to whole-body, asanguineous perfusion is presented in Table 2. In the early 1960s, Neely et al. showed that a 30% survival rate in dogs exposed to total asanguineous body perfusion at moderate hypothermia of 27 to 30°C for 30 minutes was possible (Neely, 1963). Only 5 of 33 animals survived long term without any complications. The animals that survived were exposed to only 20 minutes or less of asanguineous perfusion. Even though this was an attempt to understand the mechanism of mammalian reaction to total blood replacement, the results show that experimental conditions were suboptimal.