By S. González-Moreno
This booklet reports present examine in peritoneal malignant dissemination, from its pathogenesis and molecular mechanisms to the newest medical trials. The e-book covers the necessities of perioperative intraperitoneal chemotherapy and glossy histopathological overview of peritoneal floor malignancy. The book’s old point of view at the unfolding of recent wisdom issues the way in which for destiny study. members contain prime specialists, between them the pioneers who gave delivery to this new period in oncology.
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Additional info for Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research, Volume 169)
Cytological samples were stained with monoclonal antibodies against tumor-associated antigens (CEA, CA19-9, Ber EP4), and no unwarranted reactions were found in the control samples. With immunocytochemical detection of peritoneal micrometastasis in gastric cancer it was possible to identify free cancer cells in 35% of the patients, with a 14% improvement over routine cytopathology results . Furthermore, combining the conventional method with immunocytological studies provided more sensitive results than the conventional staining alone .
Jpn J Cancer Res 78:748– 755 45. Van Groeningen CJ, Peters GJ, Schornagel JH et al. (2000) Phase I clinical and pharmacologic study 23 of oral S-1 in patients with advanced gastric solid tumor. J Clin Oncol 18:2772–2779 46. Hirata K, Horikoshi N, Aiba K et al. (1999) Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug. Clin Cancer Res 5:2000–2005 47. Yonemura Y et al. (2006) The usefulness of oral TS1 treatment for potentially curable gastric cancer patients with intraperitoneal free cancer cells.
In general it has been considered that the serosal surface provides a local barrier to 26 tumour penetration and this is certainly true in areas where the serosal surface is flat. The serosa itself consists of a layer of mesothelial cells and their associated collagenous basement membrane, underneath which there is loose connective tissue that contains blood vessels, lymphatics and nerves – the subserosa. Whilst involvement of the subserosa by tumour is a common occurrence, this does not have the same potential for transcoelomic spread as true serosal involvement, where there is ulceration of the mesothelial layer by tumour, with tumour cells gaining access to the peritoneal space (vide infra).