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By Silvio Garattini

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Extra resources for Advances in Pharmacology and Chemotherapy Volume 13

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Spirotrypan An arsenical compound that has only limited value in the treatment of T . cruzi infections in vivo, spirotrypan showed activity only against extracellular forms and was unable to hinder the development of intracellular stages in infected HeLa cells (Mieth and Seidenhat, 1967). 6. Trypacidin An antibiotic isolated from Aspergillus fumigatus , trypacidin kills epimastigotes in LIT medium but is not very active against trypomastigote metacyclic forms. In human heart-tissue cells infected with T.

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And Castellani, 0. (1959). Exp. Parasitol. 8, 480485. Fernandes, J. , and Castellani, 0. (1966). Exp. Parasitol. 18, 195-202. Fernandes, J. , and Castellani, 0. (1968). In “Mode of Action of Anti-Parasitic Drugs” (J. Rodrigues da Silva and M. J. ), pp. 93-104. Pergamon, Oxford. Fernandes, J. , Pereira, J. P. , and Silva, L. H. P. (1959). Exp. Parasitol. 8, 496501. Fernandes, J. , Halsrnan. , and Castellani, 0. (1965). Nature (London) 207, 10041005. , and Paris, J. (1969). Ann. Trop. Med. Parasitol.

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