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By Silvio Garattini

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Extra resources for Advances in Pharmacology and Chemotherapy Volume 19

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And resistant L1210 leukemia (Wheeler et u / . , 1980). The range of AA is comparable to the normal variation in assays using a single cell line (Weinkam and Deen, 1982)and those caused by periodic changes in serum used to supplement culture media (Hahn et d . , 1974). Rapidly dividing and stationary phase cells are equally sensitive for most cell types. This 20 ROBERT J . ,1976) while stationary phase CHO hamster ovary (Tobey and Chrissman, 1975) and L1210 mouse leukemia cells (Bhuyan et ( I / .

16, 103. , Bowie, D. , Gutin, P. H . , Zito. D. , and Walker, M. D. (1977). \. 37, 2262-2266. , and Sargent, S. (1978). Riochetn. Phrrrmtrcol. 27. 1359-1363. Hung, D. , Deen, D. , and Marton, L. J. (1981). Ctrnrcv R t l . 41, 27832785. Johnston, T. , and Opliger, P. S. J . M d . Clrrni. 10, 675-681. Johnston, T. , McCaleb, G . , and Montgomery, J . A. (1963). J . M e d . Clrrrn. 6, 669-681, Johnston, T. , McCaleb, G . , Opliger, P. , and Montgomery, J. A. (1966). J . Mrci. Cheor. 9 , 892-91 I .

1975; Reed and May, 1975). Deuteration of the cyclohexyl ring also changes the distribution of hydroxylation (Farmer et ( I / . , 1978). Ring hydroxylated products are also formed in v i w in rats and man. \ -3hydroxy, 4%; trcrris -3-hydroxy, 23%; and trtrns-2-hydroxy, 8%. During this period, 96% of the CCNU was metabolized (Hilton and Walker, 25 CHLOROETHYLNITROSOUREA 1975b). In addition to ring hydroxylation, thioacetic acid has been identified as a major urinary product from [ l''C]chloroethyl-CCNU (Reed and May, 1975).

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